It has been found that topical application of retinoic acid (0.025%) to chronically photodamaged skin regenerated and restored elastic fibers, and that there was a significant positive correlation between the amount of newly regenerated elastic fiber and the wrinkle improvement caused by retinoic acid. Retin-A gel contains the active ingredient tretinoin 0.025%, which is a form of vitamin A used in the treatment of acne. It is not known exactly how tretinoin works, but it is thought to loosen the cells in the surface of the skin. This helps to unblock pores, so that the skin's natural oil producing glands can function normally. In addition, tretinoin increases the turnover of the skin cells, which aids the natural exfoliation of the outer layers of skin. This also helps to unblock pores and decrease the formation of blackheads (comedones) and spots. 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