Pulmonary arterial hypertension (PAH) has an estimated prevalence of 15 to 50 cases per million persons, but occurs with greater frequency in certain patient populations, including persons with HIV, systemic sclerosis, and/or sickle cell disease. PAH is diagnosed when the mean pulmonary arterial pressure (m PAP) is 25 mm Hg or higher at rest (normal m PAP, ≤20 mm Hg). Many physicians consider an m PAP of 21 mm Hg to 24 mm Hg as borderline elevated and of uncertain clinical significance. Once diagnosed, treatment focuses on reducing symptoms, slowing disease progression, and improving quality of life. This is often achieved through lifestyle changes, pharmacologic interventions, and surgery in select cases. What follows is a brief overview of some of the medications that are currently used to treat PAH. 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