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    Pulmonary arterial hypertension (PAH) has an estimated prevalence of 15 to 50 cases per million persons, but occurs with greater frequency in certain patient populations, including persons with HIV, systemic sclerosis, and/or sickle cell disease. PAH is diagnosed when the mean pulmonary arterial pressure (m PAP) is 25 mm Hg or higher at rest (normal m PAP, ≤20 mm Hg). Many physicians consider an m PAP of 21 mm Hg to 24 mm Hg as borderline elevated and of uncertain clinical significance. Once diagnosed, treatment focuses on reducing symptoms, slowing disease progression, and improving quality of life. This is often achieved through lifestyle changes, pharmacologic interventions, and surgery in select cases. What follows is a brief overview of some of the medications that are currently used to treat PAH. Patients with PAH often have high levels of endothelin, a group of vasoconstrictive peptides. zithromax vs levaquin -kə, and Tadacip for the treatment of pulmonary arterial hypertension. It initially was developed by the biotechnology company ICOS, and then again developed and marketed worldwide by Lilly ICOS, LLC, the joint venture of ICOS Corporation and Eli Lilly and Company. Food and Drug Administration (FDA) approved Cialis for treating the signs and symptoms of benign prostatic hyperplasia (BPH) as well as a combination of BPH and erectile dysfunction when the conditions coincide. Cialis tablets, in 2.5 mg, 5 mg, 10 mg, and 20 mg doses, are yellow, film-coated, and almond-shaped. The approved dose for pulmonary arterial hypertension is 40 mg (two 20 mg tablets) once per day (OD). On November 21, 2003 the FDA approved tadalafil (as Cialis) for sale in the United States as the third ED prescription drug pill (after sildenafil citrate (Viagra) and vardenafil (Levitra)). Like sildenafil and vardenafil, tadalafil is recommended as an 'as needed' medication. Tadalafil was approved in May 2009 in the United States for the treatment of pulmonary arterial hypertension and is under regulatory review in other regions for this condition. In late November 2008, Eli Lilly sold the exclusive rights to commercialize tadalafil for pulmonary arterial hypertension in the United States to United Therapeutics for an upfront payment of $150 million.

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