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    Edema associated with congestive heart failure (CHF), liver cirrhosis, and renal disease, including nephrotic syndrome 20-80 mg PO once daily; may be increased by 20-40 mg q6-8hr; not to exceed 600 mg/day Alternative: 20-40 mg IV/IM once; may be increased by 20 mg q2hr; individual dose not to exceed 200 mg/dose Refractory CHF may necessitate larger doses Excessive diuresis may cause dehydration and electrolyte loss in elderly; lower initial dosages and more gradual adjustments are recommended (eg, 10 mg/day PO)Increase in blood urea nitrogen (BUN) and loss of sodium may cause confusion in elderly; monitor renal function and electrolytes Anaphylaxis Anemia Anorexia Diarrhea Dizziness Glucose intolerance Glycosuria Headache Hearing impairment Hyperuricemia Hypocalcemia Hypokalemia Hypomagnesemia Hypotension Increased patent ductus arteriosus during neonatal period Muscle cramps Nausea Photosensitivity Rash Restlessness Tinnitus Urinary frequency Urticaria Vertigo Weakness Toxic epidermal necrolysis, Stevens-Johnson Syndrome, erythema multiforme, drug rash with eosinophila and systemic symptoms, acute generalized exanthematous pustulosis, exfoliative dermatitis, bullous pemphigoid purpura, pruritus Agent is potent diuretic that, if given in excessive amounts, may lead to profound diuresis with water and electrolyte depletion Careful medical supervision is required; dosing must be adjusted to patient's needs Use caution in systemic lupus erythematosus, liver disease, renal impairment Concomitant ethacrynic acid therapy (increases risk of ototoxicity) Risks of fluid or electrolyte imbalance (including causing hyperglycemia, hyperuricemia, gout), hypotension, metabolic alkalosis, severe hyponatremia, severe hypokalemia, hepatic coma and precoma, hypovolemia (with or without hypotension) Do not commence therapy in hepatic coma and in electrolyte depletion until improvement is noted IV route twice as potent as PO Food delays absorption but not diuretic response May exacerbate lupus Possibility of skin sensitivity to sunlight Prolonged use in premature neonates may cause nephrocalcinosis Efficacy is diminished and risk of ototoxicity increased in patients with hypoproteinemia (associated with nephrotic syndrome); ototoxicity is associated with rapid injection, severe renal impairment, use of higher than recommended doses, concomitant therapy with aminoglycoside antibiotics, ethacrynic acid, or other ototoxic drugs To prevent oliguria, reversible increases in BUN and creatinine, and azotemia, monitor fluid status and renal function; discontinue therapy if azotemia and oliguria occur during treatment of severe progressive renal disease FDA-approved product labeling for many medications have included a broad contraindication in patients with a prior allregic reaction to sulfonamides; however, recent studies have suggested that crossreactivity between antibiotic sulfonamides and nonantibiotic sulfonamides is unlikely to occur In cirrhosis, electrolyte and acid/base imbalances may lead to hepatic encephalopathy; prior to initiation of therapy, correct electrolyte and acid/base imbalances, when hepatic coma is present High doses ( 80 mg) of furosemide may inhibit binding of thyroid hormones to carrier proteins and result in transient increase in free thyroid hormones, followed by overall decrease in total thyroid hormone levels In patients at high risk for radiocontrast nephropathy furosemide can lead to higher incidence of deterioration in renal function after receiving radiocontrast compared to high-risk patients who received only intravenous hydration prior to receiving radiocontrast Observe patients regularly for possible occurrence of blood dyscrasias, liver or kidney damage, or other idiosyncratic reactions Cases of tinnitus and reversible or irreversible hearing impairment and deafness reported Hearing loss in neonates has been associated with use of furosemide injection; in premature neonates with respiratory distress syndrome, diuretic treatment with furosemide in the first few weeks of life may increase risk of persistent patent ductus arteriosus (PDA), possibly through a prostaglandin-E-mediated process Excessive diuresis may cause dehydration and blood volume reduction with circulatory collapse and possibly vascular thrombosis and embolism, particularly in elderly patients Increases in blood glucose and alterations in glucose tolerance tests (with abnormalities of fasting and 2 hour postprandial sugar) have been observed, and rarely, precipitation of diabetes mellitus reported Patients with severe symptoms of urinary retention (because of bladder emptying disorders, prostatic hyperplasia, urethral narrowing), the administration of furosemide can cause acute urinary retention related to increased production and retention of urine; these patients require careful monitoring, especially during initial stages of treatment Hypokalemia may develop with furosemide, especially with brisk diuresis, inadequate oral electrolyte intake, when cirrhosis is present, or during concomitant use of corticosteroids, ACTH, licorice in large amounts, or prolonged use of laxatives Pregnancy category: C; treatment during pregnancy necessitates monitoring of fetal growth because of risk for higher fetal birth weights Lactation: Drug excreted into breast milk; use with caution; may inhibit lactation Loop diuretic; inhibits reabsorption of sodium and chloride ions at proximal and distal renal tubules and loop of Henle; by interfering with chloride-binding cotransport system, causes increases in water, calcium, magnesium, sodium, and chloride Solution: Fructose10W, invert sugar 10% in multiple electrolyte #2 Additive: Amiodarone (at high concentrations of both drugs), buprenorphine, chlorpromazine, diazepam, dobutamine, eptifibatide, erythromycin lactobionate, gentamicin(? ), isoproterenol, meperidine, metoclopramide, netilmicin, papaveretum, prochlorperazine, promethazine Syringe: Caffeine, doxapram, doxorubicin, eptifibatide, metoclopramide, milrinone, droperidol, vinblastine, vincristine Y-site: Alatrofloxacin, amiodarone (incompatible at furosemide 10 mg/m L; possibly compatible at 1 mg/m L), chlorpromazine, ciprofloxacin, cisatracurium (incompatible at cisatracurium 2 mg/m L; possibly compatible at 0.1 mg/m L), clarithromycin, diltiazem, diphenhydramine, dobutamine, dopamine, doxorubicin (incompatible at furosemide 10 mg/m L and doxorubicin 2 mg/m L; possibly compatible at furosemide 3 mg/m L and doxorubicin 0.2 mg/m L), droperidol, eptifibatide, esmolol, famotidine(? ), fenoldopam, gatifloxacin, gemcitabine, gentamicin(? ), hydralazine, idarubicin, labetalol, levofloxacin, meperidine, metoclopramide, midazolam, milrinone, morphine, netilmicin, nicardipine, ondansetron, quinidine, thiopental, vecuronium, vinblastine, vincristine, vinorelbine Not specified: Tetracycline Additive: Cimetidine, epinephrine, heparin, nitroglycerin, potassium chloride, verapamil Syringe: Heparin Y-site: Epinephrine, fentanyl, heparin, norepinephrine, nitroglycerin, potassium chloride, verapamil(? ), vitamins B and C Injection: Inject directly or into tubing of actively running IV over 1-2 minutes Administer undiluted IV injections at rate of 20-40 mg/min; not to exceed 4 mg/min for short-term intermittent infusion; in children, give 0.5 mg/kg/min, titrated to effect Use infusion solution within 24 hours The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. buy cialis online with american express Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product Solution, Injection: Generic: 10 mg/m L (2 m L, 4 m L, 10 m L)Solution, Injection [preservative free]: Generic: 10 mg/m L (2 m L, 4 m L, 10 m L)Solution, Oral: Generic: 8 mg/m L (5 m L [DSC], 500 m L); 10 mg/m L (60 m L, 120 m L)Tablet, Oral: Lasix: 20 mg Lasix: 40 mg, 80 mg [scored]Generic: 20 mg, 40 mg, 80 mg Primarily inhibits reabsorption of sodium and chloride in the ascending loop of Henle and proximal and distal renal tubules, interfering with the chloride-binding cotransport system, thus causing its natriuretic effect (Rose 1991). Minimally hepatic Urine (Oral: 50%, IV: 80%) within 24 hours; feces (as unchanged drug); nonrenal clearance prolonged with renal impairment Diuresis: Oral, sublingual: 30 to 60 minutes; IM: 30 minutes; IV: ~5 minutes Symptomatic improvement with acute pulmonary edema: Within 15 to 20 minutes; occurs prior to diuretic effect Peak effect: Oral: 1 to 2 hours Oral, sublingual: 6 to 8 hours; IV: 2 hours Normal renal function: 0.5 to 2 hours; End-stage renal disease (ESRD): 9 hours 91% to 99%; primarily to albumin Edema: Management of edema associated with heart failure and hepatic or renal disease; acute pulmonary edema. Note: Not recommended for the initial treatment of hypertension (ACC/AHA [Whelton 2017]). Hypersensitivity to furosemide or any component of the formulation; anuria Canadian labeling: Additional contraindications (not in US labeling): Hypersensitivity to sulfonamide-derived drugs; complete renal shutdown; hepatic coma and precoma; uncorrected states of electrolyte depletion, hypovolemia, dehydration, or hypotension; jaundiced newborn infants or infants with disease(s) capable of causing hyperbilirubinemia and possibly kernicterus; breast-feeding. Note: Manufacturer labeling for Lasix Special and Furosemide Special Injection also includes: GFR 20 m L/minute; hepatic cirrhosis; renal failure accompanied by hepatic coma and precoma; renal failure due to poisoning with nephrotoxic or hepatotoxic substances. Note: Although the approved product labeling states this medication is contraindicated with other sulfonamide-containing drug classes, the scientific basis of this statement has been challenged. Note: Oral dose equivalency (approximate) for patients with normal renal function (Brater 1983; Cody 1994; Vargo 1995): Furosemide 40 mg = bumetanide 1 mg = ethacrynic acid 50 mg = torsemide 20 mg Acute pulmonary edema: IV: Initial: 40 mg/dose. If response not adequate within 1 hour, may increase to 80 mg/dose.

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    Investigations into the mode of action of LASIX have utilized micropuncture studies in rats, stop. The duration of diuretic effect is 6 to 8 hours. 1. Reference ID. cialis to buy online Drug Therapy Protocols Furosemide frusemide. To ensure a consistent procedural approach to Furosemide frusemide administration. Duration IV. Int J Clin Pharmacol Ther Toxicol. 1984 Dec;2212659-64. Diuretic effect and duration of action of a single intravenous dose of furosemide in uremia and.

    hypokalemia; hypochloremic alkalosis; asymptomatic hyperuricemia; fluid and electrolyte imbalances, including dilutional hyponatremia, hypocalcemia, hypomagnesemia; hyperglycemia; impaired glucose tolerance. daily in morning, with second dose given in 6 to 8 hours, carefully adjusted up to 600 mg daily, p.r.n. Use cautiously in pregnant women, patients with sulfa allergy, and in those with hepatic cirrhosis. Duration of action is 6 to 8 hours after oral administration and about 2 hours after I. Contraindicated if increased azotemia, oliguria, or progressive renal disease occur during therapy. Diuresis begins in 30 to 60 minutes and peaks 1 to 2 hours after oral administration. Excretion: About 50% to 80% of a dose is excreted in urine; plasma half-life is about 30 minutes. Contraindicated in patients hypersensitive to drug and patients with anuria, hepatic coma, or severe electrolyte depletion. Increased by 20 mg q 2 hours until desired response is achieved. Food delays oral absorption but doesn’t alter diuretic response. administration within 5 minutes and peaks in 20 to 60 minutes. Absorption: About 60% of a dose is absorbed from the GI tract after oral administration. Antihypertensive action: This drug effect may be the result of renal and peripheral vasodilatation and a temporary increase in glomerular filtration rate and a decrease in peripheral vascular resistance. Absorption: 60–67% absorbed after oral administration (↓ in acute HF and in renal failure); also absorbed from IM sites. Metabolism and Excretion: Minimally metabolized by liver, some nonhepatic metabolism, some renal excretion as unchanged drug. TIME/ACTION PROFILE (diuretic effect)CNS: blurred vision, dizziness, headache, vertigo EENT: hearing loss, tinnitus CV: hypotension GI: anorexia, constipation, diarrhea, dry mouth, dyspepsia, ↑ liver enzymes, nausea, pancreatitis, vomiting GU: ↑ BUN, excessive urination, nephrocalcinosis Derm: Edema PO: (Adults) 20–80 mg/day as a single dose initially, may repeat in 6–8 hr; may ↑ dose by 20–40 mg q 6–8 hr until desired response. Distribution: Crosses placenta, enters breast milk. Maintenance doses may be given once or twice daily (doses up to 2.5 g/day have been used in patients with HF or renal disease). Hypertension– 40 twice daily initially (when added to regimen, ↓ dose of other antihypertensives by 50%); adjust further dosing based on response; Hypercalcemia– 120 mg/day in 1–3 doses. PO: (Children 1 mo): 2 mg/kg as a single dose; may be ↑ by 1–2 mg/kg q 6–8 hr (maximum dose = 6 mg/kg). IM: IV: (Adults) 20–40 mg, may repeat in 1–2 hr and ↑ by 20 mg every 1–2 hr until response is obtained, maintenance dose may be given q 6–12 hr; Continuous infusion– Bolus 0.1 mg/kg followed by 0.1 mg/kg/hr, double q 2 hr to a maximum of 0.4 mg/kg/hr. IM: IV: Children 1–2 mg/kg/dose q 6–12 hr; Continuous infusion– 0.05 mg/kg/hr, titrate to clinical effect. Hypertension PO: (Adults) 40 twice daily initially (when added to regimen, ↓ dose of other antihypertensives by 50%); adjust further dosing based on response. Tablets: 20 mg, 40 mg, 80 mg, 500 mg Cost: Generic: 20 mg $6.50/100, 40 mg $7.11/100, 80 mg $10.83/100Oral solution (10 mg/m L–orange flavor, 8 mg/m L–pineapple–peach flavor): 8 mg/m L, 10 mg/m LCost: Generic: 10 mg/m L $10.40/60 m LSolution for injection: 10 mg/m LLab Test Considerations: Monitor electrolytes, renal and hepatic function, serum glucose, and uric acid levels before and periodically throughout therapy. May cause ↓ serum sodium, calcium, and magnesium concentrations. May also cause ↑ BUN, serum glucose, creatinine, and uric acid levels.furosemide is a sample topic from the Davis's Drug Guide.

    Lasix duration

    Diuretic Dosing Key to HF Length of Stay Medpage Today, Furosemide frusemide - Queensland Ambulance Service

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  3. Describes the medication furosemide Lasix, a drug used to treat excessive. The onset of action after injection is five minutes and the duration of diuresis is.

    • Furosemide, Lasix Drug Facts, Side Effects and Dosing - MedicineNet
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    Jun 30, 2015. Keywords Loop diuretics, Furosemide, Chronic kidney disease. this response gradually declined during the one year follow-up period. what are sertraline tablets ROUTE, ONSET, PEAK, DURATION. PO, 30–60 min, 1–2 hr, 6–8 hr. IM, 10–30 min, unknown, 4–8 hr. IV, 5 min, 30 min, 2 hr. FUROSEMIDE LASIX Onset & Duration. Onset PO 30-60 min IV Within 15-20 min; Duration 4-6 hr.

     
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    Oral: 15 to 20 mg/kg/day (based on the trimethoprim component) orally daily in 4 equally divided doses every 6 hours for 14 to 21 days IV: 15 to 20 mg/kg/day (based on the trimethoprim component) IV daily in 3 or 4 equally divided doses every 6 to 8 hours for up to 14 days Comments: -IV formulation: One investigator noted that a total daily dose of 10 to 15 mg/kg was sufficient in 10 adult patients with normal renal function. Use: For the treatment of documented Pneumocystis jiroveci pneumonia -Sulfamethoxazole-trimethoprim 800 mg-160 mg (1 double strength tablet) orally once a day -Maximum dose: The total daily dose should not exceed 1600 mg sulfamethoxazole and 320 mg trimethoprim Use: For prophylaxis against P jiroveci pneumonia in individuals who are immunosuppressed and considered to be at an increased risk of developing P jiroveci pneumonia Oral: Sulfamethoxazole-trimethoprim 800 mg-160 mg orally every 12 hours for 10 to 14 days IV: Severe infection: 8 to 10 mg/kg/day (based on the trimethoprim component) IV in 2 to 4 equally divided doses every 6, 8, or 12 hours for up to 14 days; maximum recommended dose is 960 mg (based on the trimethoprim component) per day Use: For the treatment of severe or complicated urinary tract infections due to susceptible strains of Escherichia coli, Klebsiella species, Enterobacter species, Morganella morganii, Proteus mirabilis, and Proteus vulgaris Oral: Sulfamethoxazole-trimethoprim 800 mg-160 mg (1 double strength tablet or 2 single strength tablets) orally every 12 hours for 5 days IV: Severe infection: 8 to 10 mg/kg/day (based on the trimethoprim component) IV in 2 to 4 equally divided doses every 6, 8, or 12 hours for 5 days; maximum recommended dose is 960 mg (based on the trimethoprim component) per day Comments: -The patient should be instructed to use extraordinary sanitary precautions since Shigella is transmitted by the fecal-oral route, primarily by hand-to-mouth contact. Use: For the treatment of enteritis caused by susceptible strains of Shigella flexneri and Shigella sonnei Sulfamethoxazole-trimethoprim 800 mg-160 mg (1 double strength tablet or 2 single strength tablets) orally every 12 hours for 14 days Use: For acute exacerbations of chronic bronchitis due to susceptible strains of Streptococcus pneumoniae or Haemophilus influenzae when the physician deems that sulfamethoxazole and trimethoprim could offer some advantage over the use of a single antimicrobial agent Sulfamethoxazole-trimethoprim 800 mg-160 mg (1 double strength tablet or 2 single strength tablets) orally every 12 hours for 5 days Use: For the treatment of traveler's diarrhea due to susceptible strains of enterotoxigenic E coli Uncomplicated: Sulfamethoxazole-trimethoprim 800 mg-160 mg (1 double strength tablet) orally every 12 hours for 10 days Use: Uncomplicated pyelonephritis (off-label use) Sulfamethoxazole-trimethoprim 800 mg-160 mg (1 double strength tablet) orally every 12 hours for 10 to 14 days Use: Otitis media (off-label use in adults) Sulfamethoxazole-trimethoprim 400 mg-80 mg (1 single-strength tablet) orally once a day or 3 times a week at bedtime Comments: -Some clinicians recommend that their female patients take this low dose postcoitally or 3 times a week, whichever is less frequent. Therapy should be continued for as long as the patient is at risk for infection. Use: Cystitis prophylaxis (off-label use) Sulfamethoxazole-trimethoprim 800 mg-160 mg (1 double strength tablet) orally 2 times a day for at least 3 weeks Use: Granuloma inguinale (off-label use) 10 to 20 mg/kg (based on the trimethoprim component) IV every 6 to 12 hours Comments: Use in combination with chloramphenicol is an alternative for patients with beta-lactam allergy Use: Bacterial meningitis (off-label use) Cutaneous infection: 5 to 10 mg/kg/day (based on the trimethoprim component) IV or orally in 2 to 4 divided doses Severe infection (pulmonary/cerebral): 15 mg/kg/day (based on the trimethoprim component) in 2 to 4 divided doses for 3 to 4 weeks, then 10 mg/kg/day (based on the trimethoprim component) in 2 to 4 divided doses; may be initiated IV and converted to oral therapy (frequently converted to approximate dosages of oral solid dosage forms: 2 double strength tablets [320 mg-1600 mg] every 8 to 12 hours) Duration: Not well standardized; most experts recommend at least 6 months for local disease in immunocompetent patients and 6 to 12 months or more for immunocompromised patients or patients with CNS disease Comments: -Off-label use. Maximum plasma concentrations (Cmax) of 100 to 150 mcg/m L are recommended. Severe disease is often treated with addition of other agents, such as ceftriaxone, imipenem, or amikacin. Sulfamethoxazole-trimethoprim 800 mg-160 mg (1 double strength tablet) orally every 12 hours Duration: Acute, 10 to 14 days; chronic, 1 to 3 months Comments: -Off-label use. Does Cipro contain Sulfa? - cialis levitra viagra comparison UpToDate Ear Infection Medications - GoodRx
     
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