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    Please note: This article was published more than one year ago. Oral erectile dysfunction (ED) drugs, which belong to a class of medications called phosphodiesterase 5 (PDE5) inhibitors, are widely used and highly effective but can cause such side effects as headache, upset stomach, nasal congestion, facial flushing and hearing and vision problems. The facts and conclusions presented may have since changed and may no longer be accurate. Questions about personal health should always be referred to a physician or other health care professional. 18, 2009 (Health Day News) -- A topical cream for erectile dysfunction shows promise in animal testing and could become an alternative for men who can't tolerate the pill form of the drugs, U. Men who've recently had a heart attack or have severe heart disease have to use oral ED drugs with caution, if at all. The new cream consists of nanoparticles that can carry drugs or other substances, such as nitric oxide, and deliver them in a controlled and sustained manner, according to the researchers, who are from Albert Einstein College of Medicine at Yeshiva University in New York City. Nitric oxide is the signaling molecule that dilates blood vessels responsible for creating an erection. The nanoparticle therapy was tested on 18 rats bred to have age-related ED. Some rats received nanoparticles with nitric oxide, others received nanoparticles with nitric oxide plus an experimental ED drug called silorphin (which has a different mechanism of action than PDE5 inhibitors) and a third group of rats received nanoparticles with nitric oxide and the PDE5 inhibitor tadalafil (Cialis). Five of seven of the rats that received nanoparticles with nitric oxide and all 11 rats that received nanoparticles with nitric oxide and either silorphin or tadalafil showed significant improvements in erectile function."The response time to the nanoparticles was very short, just a few minutes, which is basically what people want in an ED medication," study co-author Dr. Friedman, a professor of physiology, biophysics and medicine, said in a news release from the university. National Institute of Diabetes and Digestive and Kidney Diseases has more about erectile dysfunction. Michelle Mc Lean is a well known international media personality, entrepreneur and philanthropist. She started her international modeling career at the age of 13 years and won the Miss Universe title in 1992 at the age of 19 years for Namibia. From 1993 to 1994 while living in Los Angeles Michelle did acting with Sal Dano (Tom Seleck and Carrie Otis’s coach). After moving back to South Africa, Michelle became a presenter for Mnet from 1995 to 2003 hosting and presenting numerous programmes. Front Row (a magazine show), E-bucks (an e-commerce show), Buy Design (a property make-over show for SABC), Celebrity Homes (showcasing their homes for DSTV), Revlon Supermodels (a reality show for SABC) and most recently Woza Lunchtime (lifestyle show for Super Sport during the FIFA World Cup 2010). Michelle was the face of Lux Lotion in South Africa and has been the official voice of MTN for six years. Close to her heart is the Michelle Mc Lean Children Trust, which she established in 1992.

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