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This medication belongs to the class of medications called retinoids. It may decrease the number and severity of acne pimples and promote quick healing of pimples that do develop. prednisolone side effects in adults Retin-A (Tretinoin) is a topical (applied to the skin) form of Vitamin A that helps the skin renew itself. The Retin-A brand of tretinoin is used to treat acne. The Renova brand of tretinoin is used to reduce the appearance of fine wrinkles and mottled skin discoloration, and to make rough facial skin feel smoother. Tretinoin helps acne by causing the skin’s outer layer to grow more quickly and be replaced with new skin cells, which helps to reduce the formation of blackheads, whiteheads, and other acne lesions. It may take up to 2 to 4 weeks to see improvement in your acne and the full effect of the medication may not be seen until 6 to 12 weeks. 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