One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Is hydroxychloroquine sulfate Plaquenil ra support group Hydroxychloroquine neck stiff neck pain Hydroxychloroquine sulfatelupus The risk of plaquenil-induced toxic maculopathy is associated with a cumulative dose level of 1,000 grams and it usually takes 5-7 years for patients on the standard dose of 250-400 milligrams per day to reach that level. 2 Based on a dose of 200 milligrams per day for the past twenty years. Several risk factors may increase the likelihood of retinal toxicity from Plaquenil such as, age of greater than 60 years, daily dose more than 6.5 mg/kg; use of the drug more than 5 years, obesity, preexisting retinal disease and, renal or liver failure. Funny I tried Plaquenil a few times in the past just to see if I could tolerate it and after one dose the ache started then too but I never had the other symptoms as I stopped it immediately. Now I feel I need it again so I persisted and the other symptoms popped up. No one seems to know what "pre" toxic symptoms might be. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Plaquenil toxicity signs and symptoms Plaquenil Risk Calculators, The Risk of Retinal Toxicity with Plaquenil Hydroxychloroquine eye testHydroxychloroquine diagnostic studies routinelyHydroxychloroquine 200 mg tablet costPlaquenil and steroidsChloroquine phosphate fish medication Plaquenil is manufactured in only a 200 mg tablet The typical dosage is either 200 or 400 mg per day 200 mg daily puts anyone under 68 pounds at risk1 400 mg of Plaquenil daily puts anyone under 135 pounds at a higher risk for toxicity Therefore, 200mg of Plaquenil daily is going to be a safe dosage for virtually all adults13 Early Plaquenil Toxicity Detected without Bull’s Eye.. Hydroxychloroquine and eye symptoms. Chloroquine and Hydroxychloroquine Toxicity Practice.. Plaquenil-induced toxicity usually will not occur before five years of taking the drug. “Eye damage due to Plaquenil is not common,” he says. “Rarely will anybody who has good vision and minimal symptoms develop loss of central vision or ability to read if annual screening is done and visual are symptoms reported as soon as they occur so the medication can be stopped if toxicity occurs. Today, Plaquenil and other antimalarials are also used to treat and help prevent symptoms caused by certain autoimmune diseases such as rheumatoid arthritis RA, systemic lupus erythematosus, and discoid lupus, even though these diseases are not caused by malaria parasites. Common Plaquenil side effects may include headache, dizziness, ringing in your ears; nausea, vomiting, stomach pain; loss of appetite, weight loss; mood changes, feeling nervous or irritable; skin rash or itching; or. hair loss.