Although it is uncommon, lupus can also attack a patient’s liver, causing a more pronounced elevation in liver enzymes, such as ASTs and ALTs. When this happened to me, my symptoms included pervasive malaise, nausea, itching, and worsening of my overall health and lupus activity. Chloroquine amine What is the drug hydroxychloroquine used for Liver enzyme abnormality was defined as a 10-fold or greater increase in aspartate aminotransferase and alanine aminotransferase. Acute toxic hepatitis was diagnosed, which rapidly returned to normal after cessation of the suspected causative medication, hydroxychloroquine, and subsequent administration of mycophenolate mofetil. Plaquenil Hydroxychloroquine may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Hydroxychloroquine is a derivative of chloroquine that has both antimalarial and antiinflammatory activities and is now most often used as an antirheumatologic agent in systemic lupus erythematosis and rheumatoid arthritis. Hydroxychloroquine therapy has not been associated with liver function abnormalities and is an extremely rare cause of clinically apparent acute liver injury. They consulted and referred me to a gastroenterologist. My family doctor was persistent in finding an answer, and wouldn’t let my rheumatologist rest until they found one. Plaquenil and liver enzymes Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. Malaria pills chloroquineEffect of chloroquine in pregnancy and breastfeedingSynthesis of chloroquine pptDrugs for ra plaquenil andHydroxychloroquine price uk Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Plaquenil Side Effects Common, Severe, Long Term -. Hydroxychloroquine - LiverTox - NCBI Bookshelf. Plaquenil Uses, Dosage & Side Effects -. Hi Wimpy12 - I have PsA and my first biologic was Enbrel, along with Plaquenil. My doctor also tried adding in MTX, Arava, and several other DMARDS but my liver enzymes would rise. So used Enbrel alone and it worked great, have since switched to Cimzia and it is working good too. A very light or pale poop is a sign of liver trouble. The pale poop stopped after several weeks off plaquenil. The horrible itch did to. I've always relied on my doctor to keep a check on my test regarding this drug but he never once mentioned anything about my liver function test. Yet I was having the itching and pale stools. Plaquenil has never raised my liver enzymes and I have been on it for six years. The only time my ALT and AST were elevated when I was taking too much iron supplements for my anemia. Once I stopped those, the enzymes went back to normal.