She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation. Pharmacokinetics of quinine chloroquine and amodiaquine Chloroquine md anderson What type of medication is plaquenil Plaquenil and lasik Jan 05, 2020 Increased thickness of the retinal pigment epithelium-Bruchs' membrane has also been observed in early toxicity. The classic "flying saucer" sign is seen on OCT and describes a preservation of the outer retinal layers subfoveally with perifoveal loss of the ellipsoid zone on both sides of the fovea in a line scan. Nov 01, 2015 H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. V. M. Asensio-Sánchez, SD-OCT as screening test for hydroxychloroquine retinopathy The “flying saucer” sign, Archivos de la Sociedad Española de Oftalmología English Edition, 90, 7, 338, 2015. Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use. Plaquenil oct flying saucer PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION, Retinal Physician - Hydroxychloroquine Maculopathy An Update. Hydroxychloroquine side effects eyePlaquenil during surgeryRenault's disease hydroxychloroquineChloroquine bafilomycin a1 conventional autophagyChloroquine treatment for malaria In the five patients with SD OCT abnormalities, 3 had signs of early HCQ retinopathy while 2 had advanced changes. The “flying saucer” sign was present in all three of the five patients who presented with early HCQ retinopathy. Two patients presented with advanced HCQ retinopathy and moderate to severe vision loss. Spectral domain optical coherence tomography as an.. The “Flying Saucer” Sign on Spectral Domain Optical Coherence.. SD-OCT as screening test for hydroxychloroquine.. Chen, Eric. Brown, David M. Benz, Matthew S. Spectral domain optical coherence tomography as an effective screening test for hydroxychloroquine retinopathy the “flying saucer” sign. Clinical Ophthalmology Oct 4 2010. A PubMed search with “flying saucer” as keyword only produced 2 articles.4, 5 In 25 patients treated with HCQ, Chen et al. 4 found toxicity in 5 20%, 2 patients with advanced toxicity and a further 3 with early toxicity, or exhibiting the flying saucer sign 12%. SD-OCT could detect abnormalities before becoming obvious in ocular fundus. OCT of the right eye reveals a “flying saucer sign” of the macula with associated loss of the parafoveal IS/OS junction. Displacement of the inner retinal structures with loss of foveal contour unveils the “sinkhole sign” see white arrows.