I was told I didn't have to taper it like prednisone, and that I shouldn't expect any rebound type of reaction like you get when your body adjusts to being off pred. But everyone is taking a different mix of drugs and maybe you're taking something I don't that would make your doctor's recommendation for you different. Plaquenil hyperpigmentation histology Chloroquine mechanism of action lysosome Can plaquenil cause low white blood count Zydus hydroxychloroquine I would assume from this that people had sudden and quite severe flares when stopping the plaquenil. There is always the chance that some people might interpret this as withdrawal, but I think it is probably always in the eye of the beholder. Hard to determine what other people are going through and not worth seeing who it right or wrong. Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. If you're gonna experiment, I went off it cold turkey as it didn't hurt to do it that way, but you better get back on before the summer or you could experience a flare-up. With the Plaquenil I don't think you will find much relief in such a short time on it & at half of a workable dose. I have read about people stopping P & flaring up. Those who stopped it abruptly had real problems similar to what you are experiencing. If you really need to get off it, I would taper down slowly, very slowly. Again, I was surprised at how much relief I was getting and I noticed it almost immediately. The first time I did it was about 6 months after starting it because I didn't think it was doing anything for me. Turns out that the benefits come on so slowly that I didn't realize it was helping. Second time was maybe a year or so ago when I thought maybe I was getting a little better - and because of potential eye effects I thought I should try to eliminate it if possible. Abruptly stopping plaquenil Plaquenil Hydroxychloroquine Side effects, Images, Uses., What is the correct way to discontinue use of plaquenil? Plaquenil rash treatmentHydroxychloroquine and skin darkening If you are taking hydroxychloroquine for symptoms of rheumatoid arthritis, your symptoms should improve within 6 months. If your rheumatoid arthritis symptoms do not improve, or if they worsen, stop taking the drug and call your doctor. Once you and your doctor are sure the drug works for you. Hydroxychloroquine MedlinePlus Drug Information. Hydroxychloroquine plaquenil withdrawl? - LUPUS UK. Stopping plaquenil. DailyStrength. Stop taking hydroxychloroquine and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your. Aug 27, 2010 Plaquenil is one of those meds you can just stop. My rheumy told me to take a months rest from it once. I asked him about 'tapering' and he said "No - just stop it - and resume after a month." Guys, Are there side effects to stopping Plaquenil? If so, what? How soon after do you feel the effects of Sarcoidosis? Michele.