Long-term progression of hydroxychloroquine retinopathy off the drug marmor

Discussion in 'Hydroxychloroquine Plaquenil' started by Melisa565, 07-Mar-2020.

  1. techtorg Guest

    Long-term progression of hydroxychloroquine retinopathy off the drug marmor


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Retinal Toxicity Progression. Severe HCQ retinopathy often progresses even after drug cessation Researchers used multimodal imaging to study retinal and vision changes after hydroxychloroquine HCQ cessation in 22 patients with HCQ retinal toxicity. PURPOSE To characterize the stability or progression of different stages of hydroxychloroquine HCQ retinopathy up to 20 years after stopping the drug. METHODS We reviewed findings from 13 patients with initial HCQ retinopathy classified as early patchy photoreceptor damage, moderate ring of photoreceptor thinning or scotoma, or severe retinal pigment epithelial RPE damage. Chloroquine retinopathy, is a form of toxic retinopathy caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. This eye toxicity limits long-term use of the drugs.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Long-term progression of hydroxychloroquine retinopathy off the drug marmor

    Progression of Hydroxychloroquine Toxic Effects After Drug., Michael Marmor, MD's Profile Stanford Profiles

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  7. The most important predictors of hydroxychloroquine retinopathy are thought to be high-dose and long-term 5 years use, but current evidence is limited to retrospective studies, most of which.

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    Mar 15, 2019 Marmor MF, Hu J. Effect of disease stage on progression of hydroxychloroquine retinopathy. JAMA Ophthalmol. 2014 Sep. 132 91105-12. Kellner S, Weinitz S, Farmand G, Kellner U. Cystoid macular oedema and epiretinal membrane formation during progression of chloroquine retinopathy after drug cessation. Rationale for Screening. Hydroxychloroquine and CQ retinopathy are not reversible, and cellular damage may progress even after the drugs are stopped. When retinopathy is not recognized until a bull’seye appears, the disease can progress for years, often with foveal thinning and an eventual loss of visual acuity. Marmor MF, Hu J. Effect of disease stage on progression of hydroxychloroquine retinopathy. JAMA Ophthalmol. 2014 Sep. 132 91105-12. Kellner S, Weinitz S, Farmand G, Kellner U. Cystoid macular oedema and epiretinal membrane formation during progression of chloroquine retinopathy after drug cessation.

     
  8. Atovaquone/Proguanil (Malarone) Adults: 1 adult tablet daily. Chloroquine - Wikipedia Chloroquine - FDA prescribing information, side effects and uses HIGHLIGHTS OF PRESCRIBING INFORMATION
     
  9. Mr.Chocolade Guest

    TM is characterized by weakness and numbness of the limbs, deficits in sensation and motor skills, dysfunctional urethral and anal sphincter activities, and dysfunction of the autonomic nervous system that can lead to episodes of high blood pressure. Treatment for Transverse Myelitis TM - Johns Hopkins Hospital Hydroxychloroquine Plaquenil thread COVID19 Plaquenil Uses, Dosage & Side Effects -
     
  10. Alek Sandr User

    CellCept not taken on an empty stomach -- bad idea? With some meds they HAVE to be taken on an empty stomach, but Cellcept will work either way, just not quite as effectively. Again, I know this from personal experience. It just didn't work for me to take it on an empty stomach, and my Dr okay'd me taking it with food -- AND it put me into "remission".

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