Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Ophthalmologic examination plaquenil Hydroxychloroquine effectiveness rheumatoid arthritis Hydroxychloroquine is considered safer than chloroquine during pregnancy and lactation. Hydroxychloroquine is rapidly absorbed from the gastrointestinal tract, and steady-state concentrations are reached after 4–6 weeks; 45% of hydroxychloroquine binds to plasma proteins that are deposited in tissues such as the liver, spleen, kidney, and lung. Plaquenil hydroxychloroquine belongs to a group of medicines called quinolines. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. PLAQUENIL can lower the convulsive threshold. Co-administration of PLAQUENIL with other antimalarials known to lower the convulsion threshold e.g. mefloquine may increase the risk of convulsions. Antiepileptics. The activity of antiepileptic drugs might be impaired if co-administered with PLAQUENIL. Methotrexate Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Antimalarials hydroxychloroquine Plaquenil Side Effects Common, Severe, Long Term -, Plaquenil Uses, Dosage & Side Effects - Plaquenil and lasik Hydroxychloroquine belongs to a group of medicines known as antimalarials. It works by preventing or treating malaria, a red blood cell infection transmitted by the bite of a mosquito. However, this medicine is not used to treat severe or complicated malaria. Hydroxychloroquine Oral Route Description and Brand Names.. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. Treatments for Rheumatoid Arthritis. Hydroxychloroquine is in a class of drugs called antimalarials. It is used to prevent and treat acute attacks of malaria. It is also used to treat discoid or systemic lupus erythematosus and rheumatoid arthritis in patients whose symptoms have not improved with other treatments. Hydroxychloroquine is commonly used alongside other disease-modifying drugs including methotrexate – especially for rheumatoid arthritis. However, some drugs can interact with hydroxychloroquine. Indigestion remedies for example, antacids including some over-the-counter preparations can stop hydroxychloroquine being absorbed. The antimalarials most often prescribed to people with lupus are Hydroxychloroquine Plaquenil® Chloroquine Aralen® Quinacrine Atabrine® 2-3; Hydroxychloroquine is prescribed the most often because it is thought to have the fewest side effects. Chloroquine and quinacrine are prescribed when hydroxychloroquine cannot be used.