Lysosomes ph and the antimalarial action of chloroquine

Discussion in 'Generic Chloroquine' started by seonow, 01-Mar-2020.

  1. mephist User

    Lysosomes ph and the antimalarial action of chloroquine


    For decades, the drug was a front-line treatment and prophylactic for malaria. In a three-page paper published Tuesday in Cell Research, scientists at the Wuhan Institute of Virology’s State Key Laboratory of Virology write that both chloroquine and the antiviral remdesivir were, individually, “highly effective” at inhibiting replication of the novel coronavirus in cell culture.

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    Chloroquine enters the red blood cell by simple diffusion, inhibiting the parasite cell and digestive vacuole. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion. In this video, I will explain into one of the main antimalarial drug, chloroquine. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive. Chloroquine analog is a diprotic weak base. The unprotonated form of chloroquine diffuses spontaneously and rapidly across the membranes of cells and organelles to acidic cytoplasmic vesicles such as endosomes, lysosomes, or Golgi vesicles and thereby increases their pH Al‐Bari 2015.

    “It’s interesting in that it really lacks a lot of details but, nevertheless, if you look at the data as presented, at least in vitro, it seems like chloroquine can be used as an early-stage drug,” he said. Their drug screen evaluated five other drugs that were not effective. Though the paper is brief, John Lednicky, a professor at the University of Florida’s Emerging Pathogens Institute, found its results intriguing.

    Lysosomes ph and the antimalarial action of chloroquine

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  5. Jul 30, 2019 Before the administration of chloroquine, the patient had only a mild skin erythema in the irradiated area, which was consistent with the radiotherapy dose she had received. On day 3 of chloroquine therapy, she developed localized brisk bullous eruptions in the irradiated area, which developed into a patch of fulminant moist desquamation.

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    Chloroquine mechanism of drug action and resistance in Plasmodium falciparum. Slater AF1. Author information 1Picower Institute for Medical Research, Manhasset, NY 11030. Quinoline-containing drugs such as chloroquine and quinine have had a long and successful history in antimalarial chemotherapy. Krogstad DJ, Schlesinger PH. The basis of antimalarial action non-weak base effects of chloroquine on acid vesicle pH. Am J Trop Med Hyg. 1987 Mar; 36 2213–220. Krogstad DJ, Schlesinger PH. Acid-vesicle function, intracellular pathogens, and the action of chloroquine against Plasmodium falciparum. N Engl J Med. 1987 Aug 27; 317 9542–549. The mode of action of chloroquine is as a weak lipophilic base where the free base passes easily through membranes 34. It accumulates in the acidic lysosome as it becomes protonated, increasing the pH of the lysosome 35, 36. Following exposure to concanamycin A, BMPR-II accumulates in the lysosome.

     
  6. Mihail_nsk54 Moderator

    There are a variety of heartburn medicines available over the counter to ease symptoms. Should I take supplements with antacids? CHLOROQUINE PHOSPHATE, USP - Sanofi Treatment for GERD Antacids
     
  7. hopertveyk Guest

    Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Feb 19, 2020 Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking hydroxychloroquine and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. Call your doctor at once if you have

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