Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Chloroquine sensitive p falciparum area Plaquenil uses and side effects Methotrexate and plaquenil treatment Ibuprofin and plaquenil Mechanism of action of hydroxychloroquine as an antirheumatic drug. Fox RI1. Author information 1Department of Rheumatology, Scripps Clinic and Research Foundation, La Jolla, CA 92037. The antimalarial agents chloroquine and hydroxychloroquine have been used widely for the treatment of rheumatoid arthritis and systemic lupus erythematosus. Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. Adverse effects. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. The most serious adverse effects affect the eye. Hydroxychloroquine Plaquenil® is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatological conditions. It is a hydroxylated version of chloroquine, with a similar mechanism of action. However, following an identical dose of. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Hydroxychloroquine anti inflammatory action Hydroxychloroquine — Arthritis Australia, Hydroxychloroquine - Wikipedia Plaquenil apsChloroquine skin pigmentationDrugs like plaquenil With Plaquenil, however, the most commonly prescribed anti-malarial, this sort of damage occurs only in 1 out of 5,000 people who take the drug for five years or more. For this reason though, it is important that you see an ophthalmologist for an exam before starting to take an anti-malarial medication for your lupus. Treating Lupus with Anti-Malarial Drugs Johns Hopkins.. Hydroxychloroquine DermNet NZ. Plaquenil Hydroxychloroquine Sulfate - Sanofi. Hydroxychloroquine is classified as an anti-malarial drug. It is similar to chloroquine and is useful in treating several forms of malaria as well as lupus erythematosus and rheumatoid arthritis. Its mechanism of action is unknown. Malarial parasites invade human red blood cells. The studies reviewed here show that chloroquine/ hydroxychloroquine has in-vitro antiviral effects and anti-inflammatory properties that may be of interest in those viral infections associated with inflammation and/or immune activation. The anti-inflammatory effects of hydroxychloroquine and chloroquine could be explained in part by the upstream interference of immune activation including inhibition of lysosomal activity.