My rheumie says that although it has been proven safe, once he finds out that I'm pregnant he's going to take me off of it. Corticosteroids (such as prednisone) are generally considered safe for use during pregnancy because they do not reach the fetus in an active form.2 Cytotoxic medications such as methotrexate are stopped during pregnancy. Also one thing you have to remember is Plaquenil takes so long to enter your body to help symptoms that it will pry take just as long to leave your system so either way your body is still going to have it in it's system why go off of it throw your body off course then try to take it again, it's like starting from fresh to get your symptoms under control. Andrea I just copied this from ***** Immunosuppressant medications, which may be prescribed for severe lupus, can cause birth defects. How to stop hydroxychloroquine Prices for plaquenil Chloroquine cipro Hydroxychloroquine HCQ is often needed to manage disease activity in systemic lupus erythematosus SLE during pregnancy. The purpose of this study was to examine lupus activity and pregnancy outcomes in women with SLE treated or not treated with HCQ during pregnancy. Hydroxychloroquine Plaquenil and prednisone are considered safe during pregnancy. Methotrexate and cyclophosphamide Cytoxan should not be used in pregnancy and should be discontinued for at least a month prior to getting pregnant. Ask your doctor to help you weigh the benefits and risks all your medications. Systematic review of hydroxychloroquine use in pregnant patients with autoimmune diseases Kirk Sperber, 1 Christine Hom, 2 Chun Peng Chao, 2 Deborah Shapiro, 1 and Julia Ash 1 1 Division of Allergy, Immunology, and Rheumatology, Department of Medicine, New York Medical College, Munger Pavilion, Valhalla, NY 10595, USA I have never taken plaquenil as I have a seizure disorder as well, however, I do know that my Rheumy told me that the only safe drug to take during pregnancy is prednisone. Most certainly I wouldn't be on it if I were to have a child. Thankfully some have had successful births on prednisone but that is a strong medication just like pain medication it can harm a baby.. Hydroxychloroquine and prednisone in pregnancy Prednisone Use During Pregnancy, Lupus and Pregnancy Tips for Living with Lupus While Pregnant Hydroxychloroquine sulfate solubilityHydroxychloroquine birth defectsPlaquenil drug assistance program Objective. To investigate the effect of hydroxychloroquine HCQ in pregnant women with systemic lupus erythematosus SLE. Methods. In SLE pregnancies of a single Dutch center 2000–2015, lupus activity and flares before and during pregnancy and postpartum were assessed using the SLE Disease Activity Index SLEDAI/SLEPDAI SLEDAI adjusted for pregnancy. Hydroxychloroquine Use in Lupus Patients during Pregnancy.. Systematic review of hydroxychloroquine use in pregnant.. Hydroxychloroquine prevents congenital heart block recurrence.. Comparing prednisone dosage change, we noted a decrease in the HCQ and an increase in the PL group. Delivery age and Apgar scores were higher in the HCQ group. Neonatal examination did not reveal congenital abnormalities, nor did a neuroophthalmological and auditory evaluation at 1.5–3 y of age. Hydroxychloroquine and lupus pregnancy. RESULTS One patient received quadritherapy heparin, platelet antiaggregant, prednisone and hydroxychloroquine, 5 received triple therapy, 3 had dual therapy, and one patient had prednisone only. The 10 patients had a pregnancy under treatment, 8 of which were completed without complications. We conducted a randomized, controlled study to assess the need for hydroxychloroquine HCQ during lupus pregnancy and to assess safety. Twenty consecutive pregnant patients with similar characteristics were enrolled. The HCQ group included eight patients with systemic lupus erythematosus SLE and two with discoid lupus erythematosus DLE.