It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Hydroxychloroquine and antacids Hydroxychloroquine dose adjustment Hydroxychloroquine internal bleeding Hydroxychloroquine sulfate tablets So glad you posted this and I now know I'm not the only one having the crazy reaction to Plaquenil. I have RA and was put on Plaquenil 1 week ago and noticed the extreme moods swings, frustration turning to extreme rage, feeling crazy, then crying over my reactions. Severe depression and anxiety, overall itching, pain and stiffness increased instead of decreased First, my mother and sister took plaquenil for lupus with good effect, so I am not just disliking it for no good reason. I also suffer from disabling bipolar disorder. For 25 years, I have gotten hypomanic during spring. Very happy, never depressed. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Plaquenil depression Is extreme fatigue a side effect of Plaquenil?, PLAQUENIL Side Effects, Reviews by Patients - Chloroquine autophagy sigmaChloroquine resistance in plasmodium falciparumPlaquenil and celexa interaction Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur. Plaquenil Side Effects Common, Severe, Long Term -. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria. Will you have Depression with Plaquenil - eHealthMe. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. Plaquenil is the devil! Worked well 1st 2 mts. After that I had issues with my vision, felt waves of nervousness, and extreme anxiety where I started to question my sanity. After several months off of plaquenil, I went back on it, deciding to stick with the 100 mg per day. I have always been very sensitive to meds. Again my fatigue improved and I began to be able to do more. But again- over several months time my anxiety, depression, and sense of distance from personal relationships began to worsen.