Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Rheumatoid arthritis methotrexate vs hydroxychloroquine Chloroquine osteoarthritis Malaria preventative chloroquine aralen How long does it take plaquenil to reach steady state Total dose of 2.5 g chloroquine phosphate or 1.5 g base in three days. The dosage for adults of low body weight and for infants and children should be determined as follows First dose 10 mg base per kg but not exceeding a single dose of 600 mg base. Oral administration of 310 mg of chloroquine daily reportedly results in peak plasma concn of about 0.125 ug/mL. If 500 mg of chloroquine is administered once weekly, peak plasma concn of the drug reportedly range from 0.15-0.25 ug/mL and trough plasma concn reportedly range from 0.02-0.04 ug/mL. Chloroquine has a high affinity for tissues of the parasite and is concentrated in its cytoplasm. As a weak base, it increases the pH of the intracellular lysosome and endosome. A more acidic medium in these organelles is needed for the parasite to affect mammalian cells. As a result, chloroquine inhibits growth and development of parasites. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine base molecular weight Quinine - Wikipedia, Chloroquine C18H26ClN3 - PubChem Hydroxychloroquine and menstrual cycleDoes plaquenil help dry eyesChloroquine concentration lysosome Kg or more 1 g chloroquine phosphate 600 mg base orally as an initial dose, followed by 500 mg chloroquine phosphate 300 mg base orally after 6 to 8 hours, then 500 mg chloroquine phosphate 300 mg base orally once a day on the next 2 consecutive days Chloroquine Dosage Guide with Precautions -. Chloroquine - an overview ScienceDirect Topics. Chloroquine diphosphate salt powder or crystals, 98.5-101.. Following oral administration of a single 600-mg dose of quinine sulfate in healthy adults, the mean plasma clearance was 0.08-0.47 L/hour per kg median 0.17 L/hour per kg and the mean plasma elimination half-life was 9.7-12.5 hours. Following oral administration of 10 mg/kg. This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms' tumor and lung cancer. This protein may act as a transporter of organic cations, and have a role in the transport of chloroquine and quinidine-related compounds in kidney. Summary of recommendations on the treatment of uncomplicated vivax malaria Amodiaquine 30 mg base/kg bw divided over 3 days as 10 mg/kg bw single daily doses combined with primaquine should be given for chloroquine -resistant vivax malaria. WHO; WHO Guidelines for the Treatment of Malaria 2006.