Personally, I will be taking this when Casodex begins to fail. Bicalutamide and Chloroquine study"Taken together, our data suggest that autophagy is a protective mechanism against androgen deprivation in HRPCa cells and that chloroquine could restore hormone dependence. I also note this: "The strategy is currently being tested in clinical trials, and preliminary results are promising. Can plaquenil cause early menopause Can you lose your hair taking hydroxychloroquine Chloroquines are expected to have diverse effects on cancer progression. Inhibition of late autophagy can affect cell survival, as well as antigen processing and presentation in the immune system. Co. Treatment of uncomplicated malaria due to susceptible strains of P. falciparum, P. malariae, P. ovale, and P. vivax. Prophylaxis of malaria in geographic areas without resistance to chloroquine. The Chloroquine Story in Cancer Continues. By Derek Lowe 10 February, 2016. Chloroquine’s effects on bladder cancer cell lines, it turns out, can be shut down by providing the cells with extra cholesterol, and those effects can be recapitulated by giving them statin drugs or disrupting their cholesterol synthesis pathways by RNA interference. The plant contains a volatile oil with a high level of thujone (see Thuja). This set of data could lead to the development of new therapeutic strategy against HRPCa."Comments and discussion would be much appreciated... The catch, though, is that it's not always possible to give patients a high enough dose of hydroxychloroquine to have an effect on their tumor cells." "Available scientific evidence does not support claims that wormwood is effective in treating cancer, the side effects of cancer treatment, or any other conditions. Chloroquine and prostate cancer Chloroquine Oral Uses, Side Effects, Interactions., Chloroquine - Cancer Therapy Advisor Tinnitus and hydroxychloroquineHydroxychloroquine for ra The safe anti-malarial drug chloroquine, an inhibitor of autophagy, dramatically increased cell death after androgen deprivation or bicalutamide treatment." This is an in vitro study, but if you were going to Africa some places they would give you Chloroquine regardless of prostate cancer. Chloroquine could restore hormone dependence" when.. The Chloroquine Story in Cancer Continues In the Pipeline. Is hydroxychloroquine a zinc ionophore? - Advanced Prostate.. Chloroquine is an established antimalarial agent that has been recently tested in clinical trials for its anticancer activity. The favorable effect of chloroquine appears to be due to its ability to sensitize cancerous cells to chemotherapy, radiation therapy, and induce apoptosis. Non-castrating treatments for BCR and metastatic prostate cancer are an area of unmet need. The aim of this study is to assess the tolerability, safety and efficacy of hydroxychloroquine in combination with itraconazole as a strategy to delay time to ADT commencement in men with BCR prostate cancer. Autophagy as a modulator and target in prostate cancer 2014 Nature Review Urology, 11, pgs. 508-514 Jason M. Farrow, Joy C. Yang & Christopher P. Evans University of California, Davis Autophagy, or 'self-eating', is an adaptive process that enables cells to cope with metabolic, toxic, and even infectious stressors.