I don't get many side effects generally, but with prednisone I DO. It does help, but this can't be a long term affair. Plaquenil is a great drug (I have no experience with it, but many people with lupus take it). I'd ask your rheumy about it and have them explain why they made that choice for you. Prednisone is an intermediate acting corticosteroid-which means it has direct anti-inflamitory properties that take effect begining in a few hours. Is plaquenil another option instead of the prednisone? It is ment to get this undercontrol now and diminish your pain. Plaquenil and coumadin interaction Plaquenil effects on liver Chloroquine eye damage Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Plaquenil works well, but very slowly. You will need to give it at least a 6 months trial, and don't expect much in the way of results for a couple of months. After that, you'll probably look back and realize one day that you just don't feel as sore as you did three or four months back. Prednisone comes as a tablet, a solution liquid, and a concentrated solution to take by mouth. Prednisone is usually taken with food one to four times a day or once every other day. Your doctor will probably tell you to take your doses of prednisone at certain times of day every day. It has not direct anti-inflamitory properties and instead works on the immune system-though the mechanism is not known. Plaq is a longer time medication it may take two months before their is a noticable difference. What time should i take my prednisone and my plaquenil Plaquenil vs. Prednisone Prescription Treatment for., Plaquenil for RA?" Rheumatoid Arthritis Community. Plaquenil hivesLevaquin reactions with plaquenilWhat medication is given with chloroquineWhat percent of people on plaquenil have eye problemsPharmacy hydroxychloroquine My Mom's Dr's wan'ts her to take both Prednisone and Plaquenil together. I have not heard of this being done. I was wondering if anyone has done both med's at the same time and the effects. Mom has Lupus like me, but she was diagnosed when she was 40 yrs old and now she is 58. She has and enlarged heart, diabetes, had a stroke, and failing kidneys. Prednisone and plaquenil -. Prednisone MedlinePlus Drug Information. Plaquenil and Prednisone. When my wife was first diagnosed with PMR in May, 2016, she was put on 15mg Pred. A month later, she was told to take 400mg of plaquenil daily, with the understanding that plaquenil would replace prednisone eventually. This rheumy tried to get her down to 5mg six months later, which was a total mistake. Use this medication regularly in order to get the most benefit from it. If you are taking it on a daily schedule, take it at the same time each day. Take this medication exactly as prescribed. Jessie, plaquenil can take up to 6 months to take effect. I was told to not not try to discontinue any of my lupus meds while my medical condition was unstable. At the time, I had a sinus infection. Jessie, 3 years ago, my doctor discontinued my plaquenil ie. hydroxychloroquen and substituted it for an older anti-malerial drug named "chloroquin".