But in those who develop joint pain, fatigue, nerve dysfunction, or fibromyalgia, symptoms can be treated with mild medications. A small percentage of people with Sjogren’s develop more severe inflammation, involving organs such as the kidneys, lungs, intestines, or brain. Macular degeneration plaquenil Plaquenil for cutaneous lupus Plaquenil and cotrimoxazole For many patients with Sjogren's, Plaquenil hydroxychloroquine has long been the go to drug that their doctors prescribe. It is often the first line of attack before other more aggressive therapies are added such as methotrexate or rituximab that have bigger impacts on the immune system. I've heard that plaquenil does help w/ fatigue as well as the pain? Is this true. Right now I am not on any Dmards but when I push myself more than like 4 hrs a day out of the house running errands, etc I totally crash w/ fatigue and pain. I take tramadol and NSAIDs but wondering if I need. Plaquenil was actually first classified as an antimalarial drug, but it is also used to treat certain rheumatic and autoimmune conditions which are unrelated to malaria. Generally, Plaquenil is a treatment option as monotherapy used alone for mild rheumatoid arthritis or as combination therapy with other DMARDs for moderate to severe disease. Your doctor may recommend artificial tears to ease the discomfort of dry eye syndrome. For these people, NYU Langone doctors may prescribe more aggressive medications. How does plaquenil work for sjogren's Sjogren's diagnosis - prescribed Plaquenil?, Plaquenil for fatigue and pain DailyStrength Plaquenil and neurontin Less common adverse effects of Plaquenil are drug-induced skin rashes. These rashes may consist of many small red bumps or bright red skin covering most of the body. The severity of the rash indicates to the clinician whether the drug needs to be stopped and even whether it will be tried again. Plaquenil Use in Autoimmune Diseases. Taking Plaquenil for Rheumatoid Arthritis. Benefits Of Plaquenil - Sjogren's World. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Hi - I just started Plaquenil 400 mg a day two week ago and I started feeling less achy and tired a few days ago. Is it possible for it to work quicker in some people? I've heard it can take months, but I must say that I haven't felt like this since I was a kid - not achy or stiff. Has anyone had a similar Funny that your rheumy said plaquenil doesn’t work. It is for joint pain and fatigue and is a disease modifier that slows the progression. Its been a life saver for meespecially for lifting the fatigue.