The study, published in The Lancet, included 542 rheumatoid arthritis patients in Europe, Latin America, Asia, and Australia. For two years, all of the patients took methotrexate pills. Plaquenil safe to take Hydroxychloroquine and peripheral neuropathy Several drugs to treat RA -- biologics Enbrel, Humira, etc. and DMARDS Plaquenil, methotrexate suppress the immune system.2 Suppressing the immune system helps slow or prevent damage to joints and other body systems. Many with RA take two immune suppressant drugs -- like Enbrel and a DMARD -- with few problems. Drug interactions are reported among people who take Plaquenil and Enbrel together. This study is created by eHealthMe based on reports of 17,132 people who take Plaquenil and Enbrel from Food and Drug Administration FDA, and is updated regularly. On eHealthMe, you can evaluate side effects and drug interactions from 16 million FDA reports. Enbrel is an arthritis medication. Plaquenil is an arthritis medication and an anti infectious agent. There may be a negative interaction between Enbrel and alcohol. There may be a negative interaction between Plaquenil and alcohol. The patients also got a weekly injection -- some got shots of the biologic drug Enbrel; others got a placebo shot. Methotrexate has long been a cornerstone of rheumatoid arthritis treatment. Plaquenil and enbrel together , Plaquenil and Enbrel drug interactions - eHealthMe Plaquenil bladder infectionPlaquenil alcohol interactionChloroquine and pregnancy My current insurance wanted me to fail on two DMARDs MTX and another one I can't remember and two biologics like Humira and Enbrel before they'd allow anything else unless the rheum wanted to talk to them and my old insurance even fought the biologics all together. First line of RA meds MTX, Plaquenil, or something else? rheumatoid. Compare Enbrel vs Plaquenil - Comprehensive Analysis by Treato. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Learn about drug interactions between etanercept subq and hydroxychloroquine oral and use the RxList drug interaction checker to check drug combinations. Enbrel Subq, Enbrel Sureclick Subq. July 15, 2008 -- In the early stages of rheumatoid arthritis, taking the drugs Enbrel and methotrexate may make remission more likely than taking methotrexate alone, a new study shows. The study. Drug Combos Effective Against Rheumatoid Arthritis. Older and newer medicine together often bring relief, study finds. Please note This article was published more than one year ago. The facts and conclusions presented may have since changed and may no longer be accurate. And "More information" links may no longer work.